MultiCell Micro and small volume Bioreactor

In cell therapy, MultiCell allows cell manipulation and differentiation such as media formulation, cell seeding, cell proliferation as well as the optimally conditioned culture of a variety of cells in vitro in a bio safety chamber.
Especially, like the bioreactor in tissue engineering to raise the artificial blood vessel by using stem cell technology, it is the bioreactor designed with the distinguished structure as the custom-made and custom-optimized for the specific purpose driven cell culture in optimum condition requested by researchers for cell therapy. Basically, with embodiment of the same level as TotiCell and PluriCell bioreactor in the major functions, the bio safety chamber, and the related accessories, it is a suitable bioreactor to the circulation structure for realizing dynamic cell culture condition, thanks to the horizontally lengthy design. In terms of a circulation cycle, duplicating an environment like a heartbeat can be raised by a pulse pump, and a device able to administer biological stimuli like a reciprocating strain can be attached to the cell culture cartridge made of flexible material, PDMS.
Furthermore, this model is relatively far more suitable to the addition of devices to impose biological stimuli like ultrasound, physical stress, etc.

There are two concepts for validating use the multitude of cell culture cartridges in the bio safety chamber. One is a thoroughly independent system that establishes the independent cell culture condition of each cell culture cartridge, infusing complex media formulated in the mixing vessel by peristaltic pumps to each cell culture cartridge. The second method is the parallel system that infuses the same quantity of complex media to the cell culture cartridge without peristaltic pumps simultaneously.
A gas mixer is used in conjunction due to its complicated structure and costliness. As occasion calls, a gas mixer system would be provided independently to each cell culture cartridge based on the customer’s specific request. Researchers could then achieve the much better quality of the product and advancement in productivity with use of the multitude of cartridges in Biotron’s bio safety chamber which is far superior to a general CO2 incubator. For this, Biotron could provide the researchers with a custom-made cell culture system.